In economic terms, the Danube is linking the non-EU zone with EU-countries, thus calling for holistic solutions along with a continuously improving networking and cooperation. Using the waterway as a main asset can help to stimulate the local development, boost cooperation between communities, and boost the potentials of small or remotely positioned communities. It also presents a unique opportunity for entire areas to become more prominent on the international stage. Could we, therefore, speak about a sustainable economic development of the Danube Region? The lecture is focused precisely on this question.